API Screening Scheme
Iimpawu zezinto eziphathekayo
Kwi-synthesis yezinto eziluhlaza kunye ne-intermediates, ubukhulu be-particle ye-particle buhluke, kwaye u-fineness we-powder ayifani, eyancipha okanye iyanqatshwa.Ngenxa yokuba umxholo wefiber yezityalo udlula umgangatho, ixabiso le powder yonyango alikwazi ukuphuculwa.Ubungakanani beepilisi zeepilisi buhluke, ubukhulu beepilisi buhluke, kwaye ukucaciswa kwezinto ezibonakalayo kuyahluka.Kukho malunga newaka leentlobo.Iimfuno ezingqongqo, azikwazi ukonakalisa, umonakalo, ezifana ne-capsule pellets izinto eziluhlaza.
Inkqubo yokuvelisa
Ukutsalwa kwezinto ezikrwada-ukuhluzwa-ikristale-ukwahlula-ukomisa-ukuhluza-ukupakishwa kwangaphakathi-ukupakishwa kwangaphandle
Ukutsalwa kwemathiriyeli ekrwada: Ngokwe-solubility yamacandelo ahlukeneyo kumayeza esintu aseTshayina kwizinyibilikisi, isinyibilikisi esinenyibiliko ephezulu yamacandelo asebenzayo kunye ne-solubility ephantsi yamacandelo angafunekiyo ukunyibilika ikhethiwe, kwaye indlela yokunyibilikisa amacandelo asebenzayo. ukusuka kwizicubu zezinto zonyango kuthiwa yi-solvent extraction.
Ukuhluzwa: Ukuhluzwa kubhekiselele ekusebenzeni kweyunithi yokwahlula amasuntswana ezinto eziqinileyo ezimiswe kwirhasi okanye kulwelo, kusetyenziswa izinto ezirhabaxa (isihluzi esiphakathi) ukudlula irhasi okanye ulwelo ekumisweni (isihluzi se-slurry) (i-filtrate), ukuvalela amasuntswana aqinileyo ( intsalela yesihluzi) eyehlayo hlala kwindawo yokucoca ukwenza ikeyiki yokucoca.
I-Crystallization: Xa isisombululo esishushu esishushu sipholile, ukunyibilika kwe-solute kuncipha kwaye isisombululo siba yi-supersaturated, ukuze i-solute iqhube ngendlela yeekristale.
Ukwahlukana: Ukwahlukana okomileyo nokumanzi.
Ukomisa: Sebenzisa ubushushu ukunyakamisa ukufuma (ukufuma okanye ezinye izinyibilikisi) kwimathiriyeli emanzi, kwaye usebenzise i-airflow okanye i-vacuum ukususa ukufuma okwenziwe ngumphunga ukufumana imathiriyeli eyomileyo.
Uvavanyo: Izinto eziphathekayo zihlelwa ngokobungakanani besuntswana.
Ukupakishwa: Ukugqiba ukupakisha.
Injongo yokuhlola
Kwi-synthesis of intermediates, ubungakanani bezinto eziphathekayo buhluke, kwaye ubumnandi bepowder abufani, obuncitshiswe okanye bukhatywe.Izinto eziphathekayo zinamathele, i-adsorbed, ihlolwe kwaye ivinjiwe, ukuma komphezulu wezinto eziphathekayo, kunye nobuninzi bobuninzi bufunekayo ngokungqongqo, kwaye ayinakonakaliswa okanye yonakaliswe, njengezinto eziluhlaza ze-capsules kunye neepellets.
