API Screening Scheme
Lintho tse bonahalang
Ha ho etsoa lihlahisoa tse tala le li-intermediates, boholo ba likaroloana tsa thepa bo fapane, 'me botle ba phofo ha bo tšoane, bo fokotsehang kapa bo haneloa.Hobane litaba tsa fiber ea limela li feta tekanyo, boleng ba phofo ea meriana bo ke ke ba ntlafatsoa.Boholo ba likaroloana tsa lipilisi bo fapane, boholo ba lipilisi bo fapane, 'me litlhaloso tsa lisebelisoa tse tala li fapane.Ho na le mefuta e ka bang sekete.Litlhokahalo tse thata, li ke ke tsa senya, li senya, joalo ka lisebelisoa tse tala tsa capsule pellets.
Mokhoa oa tlhahiso
Ho ntšoa ha thepa e tala - filtration - crystallization - karohano - ho omisa - sieving - sephutheloana se kahare - sephutheloana sa kantle
Ho ntšoa ha lisebelisoa tse tala: Ho ea ka ho qhibiliha ha likarolo tse fapaneng tsa meriana ea litlama ea Sechaena ka har'a li-solvents, mokelikeli o nang le solubility e phahameng bakeng sa likarolo tse sebetsang le ho qhibiliha ho tlase bakeng sa likarolo tse sa hlokeng ho qhibiliha ho khethoa, 'me mokhoa oa ho qhaqha likarolo tse sebetsang. ho tsoa liseleng tsa moriana o bitsoa ho ntšoa ha solvent.
Filtration: Filtration e bua ka ts'ebetso ea yuniti ea ho arola likaroloana tse tiileng tse emisitsoeng ka har'a khase kapa mokelikeli, ho sebelisa sesebelisoa sa porous (sefate sa filthara) ho fetisa khase kapa mokelikeli ka har'a ho emisoa (filter slurry) (filtrate), ho thibela likaroloana tse tiileng. filthara residue) tse theohang li lula ka har'a sesefa ho etsa kuku e sefang.
Crystallization: Ha tharollo e chesang e chesang e pholile, ho qhibiliha ha solute hoa fokotseha 'me tharollo e fetoha supersaturated, e le hore solute e fokotsehe ka mokhoa oa likristale.
Karohano: Karohano e omileng le e metsi.
Ho omisa: Sebelisa mocheso ho etsa mouoane (mongobo kapa lihlapolli tse ling) linthong tse metsi, 'me u sebelise phallo ea moea kapa vacuum ho tlosa mongobo o omileng ho fumana lisebelisoa tse omeletseng.
Screening: Thepa e hlophisoa ka boholo ba likaroloana.
Ho paka: Ho qeta ho paka.
Sepheo sa ho hlahloba
Ka ho qaptjoa ha li-intermediates, boholo ba likaroloana tsa thepa bo fapane, 'me botle ba phofo ha bo tšoane, bo fokotsehang kapa bo haneloa.Thepa e khomarela, e adsorbed, e hloekisitsoe ebile e koetsoe, sebopeho sa holim'a thepa, 'me bongata bo bongata bo hlokoa ka thata,' me e ke ke ea senyeha kapa ea senyeha, joalo ka lisebelisoa tse tala tsa capsules le pellets.
